Mixing 2C-x and MAOIs

Mixing 2C-x and MAOIs calls for caution — TripSit rates this combination “Caution.” Low risk never means safe.

MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably

2C-x (also known as 2C-B, 2C-I, 2C-E) and MAOIs (also known as some antidepressants, syrian rue).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and 2C-x
• Mixing Benzodiazepines and 2C-x
• Mixing Alcohol and 2C-x
• Mixing Cocaine and 2C-x
• Mixing Amphetamines and 2C-x
• Mixing MDMA and 2C-x
• Mixing Cannabis and 2C-x
• Mixing Ketamine and 2C-x

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.