Mixing Alcohol and DPH

Mixing Alcohol and DPH is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackouts and memory loss are significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. Alcohol may also increase the deliriant effects of diphenhydramine. It should also be noted if the individual consuming alcohol typically has a flushing response to alcohol, diphenhydramine may reduce the reaction and mask some of the effects of the alcohol.

Alcohol and DPH (also known as Benadryl).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Alcohol
• Mixing Benzodiazepines and Alcohol
• Mixing Alcohol and Cocaine
• Mixing Alcohol and Amphetamines
• Mixing Alcohol and MDMA
• Mixing Alcohol and Cannabis
• Mixing Alcohol and Ketamine
• Mixing Alcohol and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.