Mixing Alcohol and SSRIs

Mixing Alcohol and SSRIs calls for caution — TripSit rates this combination “Caution.” Low risk never means safe.

Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

Alcohol and SSRIs (also known as most antidepressants).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Alcohol
• Mixing Benzodiazepines and Alcohol
• Mixing Alcohol and Cocaine
• Mixing Alcohol and Amphetamines
• Mixing Alcohol and MDMA
• Mixing Alcohol and Cannabis
• Mixing Alcohol and Ketamine
• Mixing Alcohol and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.