Mixing Cocaine and SSRIs

Mixing Cocaine and SSRIs is relatively low-risk, with roughly additive effects — TripSit rates this combination “Low Risk & No Synergy.” Low risk never means safe.

May reduce each others' effectiveness. Cocaine can reduce mental stability and therefore exacerbate conditions which SSRIs are used to treat.

Cocaine (also known as coke, crack) and SSRIs (also known as most antidepressants).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Cocaine
• Mixing Benzodiazepines and Cocaine
• Mixing Alcohol and Cocaine
• Mixing Cocaine and Amphetamines
• Mixing Cocaine and MDMA
• Mixing Cocaine and Cannabis
• Mixing Cocaine and Ketamine
• Mixing Cocaine and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.