Mixing Nitrous oxide and SSRIs

Mixing Nitrous oxide and SSRIs is relatively low-risk, with roughly additive effects — TripSit rates this combination “Low Risk & No Synergy.” Low risk never means safe.

Nitrous oxide (also known as whippets, laughing gas) and SSRIs (also known as most antidepressants).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Nitrous oxide
• Mixing Benzodiazepines and Nitrous oxide
• Mixing Alcohol and Nitrous oxide
• Mixing Cocaine and Nitrous oxide
• Mixing Amphetamines and Nitrous oxide
• Mixing MDMA and Nitrous oxide
• Mixing Cannabis and Nitrous oxide
• Mixing Ketamine and Nitrous oxide

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.