Mixing Opioids and Amphetamines

Mixing Opioids and Amphetamines calls for caution — TripSit rates this combination “Caution.” Low risk never means safe.

Stimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.

Opioids (also known as heroin, fentanyl, oxycodone, morphine, methadone) and Amphetamines (also known as Adderall, speed, meth).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Keep naloxone (Narcan) within reach. It reverses opioid overdose and is safe to give if you are unsure.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Benzodiazepines
• Mixing Opioids and Alcohol
• Mixing Opioids and Cocaine
• Mixing Opioids and MDMA
• Mixing Opioids and Cannabis
• Mixing Opioids and Ketamine
• Mixing Opioids and GHB / GBL
• Mixing Opioids and Tramadol

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.