Mixing Amphetamines and MDMA

Mixing Amphetamines and MDMA calls for caution — TripSit rates this combination “Caution.” Low risk never means safe.

This combination of stimulants will increase strain on the heart, may cause some physical discomfort, and has the chance to cause cardiovascular issues. The anxiogenic and focusing effects of stimulants can increase the chance of unpleasant thought loops and make the experience more uncomfortable, this combination raises these chances. Amphetamines will increase the neurotoxic effects of MDMA, in addition to causing further concerns of hyperthermia due to the inherent nature of the combination. It will also raise one's body temperature, also likely making the combination more neurotoxic.

Amphetamines (also known as Adderall, speed, meth) and MDMA (also known as ecstasy, molly).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Amphetamines
• Mixing Benzodiazepines and Amphetamines
• Mixing Alcohol and Amphetamines
• Mixing Cocaine and Amphetamines
• Mixing Amphetamines and Cannabis
• Mixing Amphetamines and Ketamine
• Mixing Amphetamines and GHB / GBL
• Mixing Amphetamines and Tramadol

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.