Mixing Caffeine and MAOIs

Mixing Caffeine and MAOIs is relatively low-risk, with roughly additive effects — TripSit rates this combination “Low Risk & No Synergy.” Low risk never means safe.

Caffeine and MAOIs (also known as some antidepressants, syrian rue).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Caffeine
• Mixing Benzodiazepines and Caffeine
• Mixing Alcohol and Caffeine
• Mixing Cocaine and Caffeine
• Mixing Amphetamines and Caffeine
• Mixing MDMA and Caffeine
• Mixing Cannabis and Caffeine
• Mixing Ketamine and Caffeine

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.