Mixing Opioids and Caffeine

Mixing Opioids and Caffeine is relatively low-risk, with roughly additive effects — TripSit rates this combination “Low Risk & No Synergy.” Low risk never means safe.

Opioids (also known as heroin, fentanyl, oxycodone, morphine, methadone) and Caffeine.

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Keep naloxone (Narcan) within reach. It reverses opioid overdose and is safe to give if you are unsure.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Benzodiazepines
• Mixing Opioids and Alcohol
• Mixing Opioids and Cocaine
• Mixing Opioids and Amphetamines
• Mixing Opioids and MDMA
• Mixing Opioids and Cannabis
• Mixing Opioids and Ketamine
• Mixing Opioids and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.