Mixing Ketamine and DXM

Mixing Ketamine and DXM is relatively low-risk, and effects may be stronger together — TripSit rates this combination “Low Risk & Synergy.” Low risk never means safe.

Both substances primarily exert their effects through NMDA antagonism. Currently, there is no evidence regarding mechanisms that might reduce these effects.

Ketamine (also known as K, special K) and DXM (also known as cough syrup, Robo).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Ketamine
• Mixing Benzodiazepines and Ketamine
• Mixing Alcohol and Ketamine
• Mixing Cocaine and Ketamine
• Mixing Amphetamines and Ketamine
• Mixing MDMA and Ketamine
• Mixing Cannabis and Ketamine
• Mixing Ketamine and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.