Mixing Ketamine and DPH

Mixing Ketamine and DPH is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Ketamine has a high likelihood of increasing DPH's deliriant effects at higher dosages and can greatly increase the risk of injury, mania, and psychosis. Medical dosages of both substances are unlikely to cause concern.

Ketamine (also known as K, special K) and DPH (also known as Benadryl).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Ketamine
• Mixing Benzodiazepines and Ketamine
• Mixing Alcohol and Ketamine
• Mixing Cocaine and Ketamine
• Mixing Amphetamines and Ketamine
• Mixing MDMA and Ketamine
• Mixing Cannabis and Ketamine
• Mixing Ketamine and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.