Mixing Ketamine and MAOIs

Mixing Ketamine and MAOIs calls for caution — TripSit rates this combination “Caution.” Low risk never means safe.

MAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available

Ketamine (also known as K, special K) and MAOIs (also known as some antidepressants, syrian rue).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Ketamine
• Mixing Benzodiazepines and Ketamine
• Mixing Alcohol and Ketamine
• Mixing Cocaine and Ketamine
• Mixing Amphetamines and Ketamine
• Mixing MDMA and Ketamine
• Mixing Cannabis and Ketamine
• Mixing Ketamine and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.