Mixing MDMA and MAOIs
Mixing MDMA and MAOIs is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.
MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.
MDMA (also known as ecstasy, molly) and MAOIs (also known as some antidepressants, syrian rue).
What to do
- Avoid this combination — the safest choice is not to mix them.
- Start with much less than usual and go slow — you can always take more, never less.
- Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.
Open the interactive combination checker
Related combinations
- Mixing Opioids and MDMA
- Mixing Benzodiazepines and MDMA
- Mixing Alcohol and MDMA
- Mixing Cocaine and MDMA
- Mixing Amphetamines and MDMA
- Mixing MDMA and Cannabis
- Mixing MDMA and Ketamine
- Mixing MDMA and GHB / GBL
This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.