Mixing MDMA and Pregabalin

Mixing MDMA and Pregabalin is unsafe and best avoided — TripSit rates this combination “Unsafe.” Low risk never means safe.

There is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications. Medical dosages are not reported to be a concern

MDMA (also known as ecstasy, molly) and Pregabalin (also known as Lyrica).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and MDMA
• Mixing Benzodiazepines and MDMA
• Mixing Alcohol and MDMA
• Mixing Cocaine and MDMA
• Mixing Amphetamines and MDMA
• Mixing MDMA and Cannabis
• Mixing MDMA and Ketamine
• Mixing MDMA and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.