Mixing Opioids and DXM

Mixing Opioids and DXM is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.

Opioids (also known as heroin, fentanyl, oxycodone, morphine, methadone) and DXM (also known as cough syrup, Robo).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Keep naloxone (Narcan) within reach. It reverses opioid overdose and is safe to give if you are unsure.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Benzodiazepines
• Mixing Opioids and Alcohol
• Mixing Opioids and Cocaine
• Mixing Opioids and Amphetamines
• Mixing Opioids and MDMA
• Mixing Opioids and Cannabis
• Mixing Opioids and Ketamine
• Mixing Opioids and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.