Mixing Tramadol and DPH

Mixing Tramadol and DPH is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

Both drugs increase the risk of serotonin syndrome. While at medical dosages, this is unlikely to be of concern, recreational doses should be avoided. Diphenhydramine may increase tramadol’s seizure risk.

Tramadol and DPH (also known as Benadryl).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Keep naloxone (Narcan) within reach. It reverses opioid overdose and is safe to give if you are unsure.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Tramadol
• Mixing Benzodiazepines and Tramadol
• Mixing Alcohol and Tramadol
• Mixing Cocaine and Tramadol
• Mixing Amphetamines and Tramadol
• Mixing MDMA and Tramadol
• Mixing Cannabis and Tramadol
• Mixing Ketamine and Tramadol

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.