Mixing Tramadol and Mephedrone

Mixing Tramadol and Mephedrone is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

There is a high risk of serotonin syndrome and seizures at recreational dosages. Both substances affect the heart and may lead to further dangerous heart complications at higher dosages. Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction. The combination may increase each other's side effects, such as dizziness and drowsiness. At higher dosages, the combination may increase each other’s side effects, such as delirium, mania, and psychosis.

Tramadol and Mephedrone (also known as 4-MMC, meow meow).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Keep naloxone (Narcan) within reach. It reverses opioid overdose and is safe to give if you are unsure.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Tramadol
• Mixing Benzodiazepines and Tramadol
• Mixing Alcohol and Tramadol
• Mixing Cocaine and Tramadol
• Mixing Amphetamines and Tramadol
• Mixing MDMA and Tramadol
• Mixing Cannabis and Tramadol
• Mixing Ketamine and Tramadol

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.