Mixing Tramadol and Pregabalin

Mixing Tramadol and Pregabalin is unsafe and best avoided — TripSit rates this combination “Unsafe.” Low risk never means safe.

There is a significant risk of seizures. Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing. Medical dosages are not reported to be a concern.

Tramadol and Pregabalin (also known as Lyrica).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Keep naloxone (Narcan) within reach. It reverses opioid overdose and is safe to give if you are unsure.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Tramadol
• Mixing Benzodiazepines and Tramadol
• Mixing Alcohol and Tramadol
• Mixing Cocaine and Tramadol
• Mixing Amphetamines and Tramadol
• Mixing MDMA and Tramadol
• Mixing Cannabis and Tramadol
• Mixing Ketamine and Tramadol

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.