Mixing Amphetamines and DPH

Mixing Amphetamines and DPH calls for caution — TripSit rates this combination “Caution.” Low risk never means safe.

Amphetamines as a stimulant may mask some of the negative side effects of DPH, leading to delusions of sobriety which has additional concern in states of delirium. The combination of stimulants will increase strain on the heart and may cause some physical discomfort, and has the chance to cause life-threatening cardiovascular issues. The combination may also increase each other's neurotoxicity at higher dosages. The combination may increase anxiety levels and risks of thought loops on higher dosages, in addition to increasing each others negative side effects. Medical and common dosages of each substances are reported to not be a concern. Additionally, it is suggested that DPH potentiates amphetamine psychomotor activation, in addition to other interactions such as potentiation through inhibition of CYP2D6 and histamine H1 and H2 receptors, among other alterations.

Amphetamines (also known as Adderall, speed, meth) and DPH (also known as Benadryl).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Amphetamines
• Mixing Benzodiazepines and Amphetamines
• Mixing Alcohol and Amphetamines
• Mixing Cocaine and Amphetamines
• Mixing Amphetamines and MDMA
• Mixing Amphetamines and Cannabis
• Mixing Amphetamines and Ketamine
• Mixing Amphetamines and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.