Mixing Amphetamines and MAOIs

Mixing Amphetamines and MAOIs is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises.

Amphetamines (also known as Adderall, speed, meth) and MAOIs (also known as some antidepressants, syrian rue).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Amphetamines
• Mixing Benzodiazepines and Amphetamines
• Mixing Alcohol and Amphetamines
• Mixing Cocaine and Amphetamines
• Mixing Amphetamines and MDMA
• Mixing Amphetamines and Cannabis
• Mixing Amphetamines and Ketamine
• Mixing Amphetamines and GHB / GBL

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.