Mixing SSRIs and Lithium

Mixing SSRIs and Lithium is relatively low-risk, with roughly additive effects — TripSit rates this combination “Low Risk & No Synergy.” Low risk never means safe.

This interaction is used in medical settings without reported issues. If this combination is taken, caution would be recommended if any other drugs are planned to be taken on top of these that may have serotonergic activity.

SSRIs (also known as most antidepressants) and Lithium.

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and SSRIs
• Mixing Benzodiazepines and SSRIs
• Mixing Alcohol and SSRIs
• Mixing Cocaine and SSRIs
• Mixing Amphetamines and SSRIs
• Mixing MDMA and SSRIs
• Mixing Cannabis and SSRIs
• Mixing Ketamine and SSRIs

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.