Mixing DPH and MXE

Mixing DPH and MXE is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

There is a high risk of serotonin syndrome from this combination. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. MXE has a high likelihood of increasing DPH's deliriant effects at higher dosages and can greatly increase the risk of injury, mania, and psychosis. Medical dosages are unlikely to be of concern.

DPH (also known as Benadryl) and MXE.

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and DPH
• Mixing Benzodiazepines and DPH
• Mixing Alcohol and DPH
• Mixing Cocaine and DPH
• Mixing Amphetamines and DPH
• Mixing Ketamine and DPH
• Mixing GHB / GBL and DPH
• Mixing Tramadol and DPH

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.