Mixing DPH and Pregabalin

Mixing DPH and Pregabalin is unsafe and best avoided — TripSit rates this combination “Unsafe.” Low risk never means safe.

There is a significant risk of seizures from this combination. The combination is likely to increase each other’s negative side effects, such as nausea, dizziness, and loss of consciousness. At higher dosages, pregabalin is likely to increase diphenhydramine’s deliriant effects, inhibition, and risk of injury. Medical dosages are not reported to be a concern.

DPH (also known as Benadryl) and Pregabalin (also known as Lyrica).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and DPH
• Mixing Benzodiazepines and DPH
• Mixing Alcohol and DPH
• Mixing Cocaine and DPH
• Mixing Amphetamines and DPH
• Mixing Ketamine and DPH
• Mixing GHB / GBL and DPH
• Mixing Tramadol and DPH

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.