Mixing DPH and SSRIs

Mixing DPH and SSRIs is dangerous and should be avoided — TripSit rates this combination “Dangerous.” Low risk never means safe.

There is a high risk of serotonin syndrome at recreational dosages. Medical dosages are reported not to be a concern for the general population. The combination may increase each other's side effects, such as dizziness and drowsiness.

DPH (also known as Benadryl) and SSRIs (also known as most antidepressants).

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and DPH
• Mixing Benzodiazepines and DPH
• Mixing Alcohol and DPH
• Mixing Cocaine and DPH
• Mixing Amphetamines and DPH
• Mixing Ketamine and DPH
• Mixing GHB / GBL and DPH
• Mixing Tramadol and DPH

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.