Mixing Pregabalin and Caffeine

Mixing Pregabalin and Caffeine is unsafe and best avoided — TripSit rates this combination “Unsafe.” Low risk never means safe.

There is a risk of seizures from this combination, especially at higher dosages. Caffeine additionally reduces pregabalin’s anticonvulsant effects found in lower dosages. Caffeine increases respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications. Medical dosages are unlikely to be of concern.

Pregabalin (also known as Lyrica) and Caffeine.

What to do

• Avoid this combination — the safest choice is not to mix them.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Pregabalin
• Mixing Cocaine and Pregabalin
• Mixing Amphetamines and Pregabalin
• Mixing MDMA and Pregabalin
• Mixing Cannabis and Pregabalin
• Mixing Ketamine and Pregabalin
• Mixing GHB / GBL and Pregabalin
• Mixing Tramadol and Pregabalin

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.