Mixing Pregabalin and Nitrous oxide

Mixing Pregabalin and Nitrous oxide calls for caution — TripSit rates this combination “Caution.” Low risk never means safe.

Both substances potentiate the ataxia and sedation caused by the other, and may increase the risk of loss of consciousness at higher dosages. While unconscious, vomit aspiration is a risk if not placed in the recovery position. The combination may increase inhibition and risk of injury. Additionally, abuse of nitrous while under the influence of pregabalin may increase the risk of seizures. Medical dosages are unlikely to be a concern.

Pregabalin (also known as Lyrica) and Nitrous oxide (also known as whippets, laughing gas).

What to do

• Even for lower-risk pairs, the safest choice is not to mix — and never to use alone.
• Start with much less than usual and go slow — you can always take more, never less.
• Never use alone. If you do, call 1-800-484-3731 (Never Use Alone) so someone can send help if you stop responding.

Open the interactive combination checker

Related combinations

• Mixing Opioids and Pregabalin
• Mixing Cocaine and Pregabalin
• Mixing Amphetamines and Pregabalin
• Mixing MDMA and Pregabalin
• Mixing Cannabis and Pregabalin
• Mixing Ketamine and Pregabalin
• Mixing GHB / GBL and Pregabalin
• Mixing Tramadol and Pregabalin

This is educational information, not medical advice. "Low risk" never means "safe", and the potency of an unregulated supply is unknown.